This quantitative dependence can be described by a Hill equation, with a Hill coefficient of 2.4 ± 0.6. In the presence of DEAE-dextran, the polycation known to enhance HIV- 1 infectivity in cell culture, virion infectivity follows gp120 density as a sigmoidal dependence and reaches an apparent plateau. The resulting gp120 density per virion is then correlated with the infectivity of the virions measured in cell culture. This method involves 1) production of a set of single-cycle HIV- 1 virions with varied density of Env on their surface, 2) site-specific labeling of Env-specific antibody Fab with a fluorophore at high efficiency, and 3) optical trapping virometry to measure the number of gp120 molecules on individual HIV- 1 virions. Here we have developed a method to examine this dependence. Although in general it has been perceived that more Env gives rise to higher infectivity, the precise quantitative dependence of HIV- 1 virion infectivity on Env density has remained unknown. The envelope glycoprotein (Env) gp120/gp41 is required for HIV- 1 infection of host cells. All rights reserved.Quantitative Correlation between Infectivity and Gp120 Density on HIV- 1 Virions Revealed by Optical Trapping Virometry*ĭeSantis, Michael C. Please contact manufacturer for latest product information.ĭesignated trademarks and brands are the property of their respective owners. Images as they do not necessarily reflect the latest information availableįrom the manufacturer. Is not responsible for any incorrect or outdated product descriptions and/or Products' pictures, labeling, and descriptionsĪre subject to change by the manufacturers without notice. The Food and Drug Administration and are not intended to diagnose, treat,Ĭure, or prevent any disease. InformationĪnd statements regarding dietary supplements have not been evaluated by Medical problem, promptly contact your health care provider. You should readĪll product packaging carefully.
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